Lab P53 is the first Cancer Genomics Company in India to build a sophisticated model to bridge current trends in genomic sciences with Oncologists. Lab P53’s Personalized Cancer Therapy(PCT) will help Oncologists in selecting the best suitable treatment available for every patient, by analyzing the genomics of tumor.
Lab P53 brings you the Genomics based Personalized Cancer Therapy for the first time in india, to select the best treatment option for every individual.
To get the Personalized Cancer Therapy done, you don't need to move around anywhere. We collect your sample from your hospital's pathalogy department.
Very Minimal Sample
We require very minimal sample, i.e., 1 - 2 gms of tumour tissue extracted during biopsy. A fresh dry ice frozen sample or praffin fixed sample.
Lab P53 has a well defined work flow with sophisticated technology, we will be able to report your best suitable treatment in just 3 - 4 weeks' time.
Check out this column for more information about Lab P53, both in research and management.`
Lab P53's PCT-Personalized Cancer Therapy project is approved for incubation at VIT TBI, VIT University.
Lab P53- initiated a new phase of observational trials for its PCT with 20 liver cancer patients from Indian origin.
Lab P53 - Working towards a Cancer free Nation.
A prestigious medical practitioner (name withheld) was once summoned to give a lecture on cancer at an engineering college. Admittedly he had his reservations at first, as being from a strictly medical background he didn’t really think the young engineers would be interested in what he had to say. Thus he was met with a pleasant surprise when the students raised pertinent and rather interesting questions about all the topics that he was talking about. He later found out by a show of hands that almost half the students in that room were either directly or indirectly related to or knew someone that had cancer.
The above incident can be looked upon as a profound eye-opener, but it can also be observed as a progressive step in the “War against Cancer”. These engineers although not strictly from a medical background, have motive to make a determined effort to understand and fight cancer and as a contribution toward the same biological sciences and information technology are coming together in the form of sequencing and genome analysis in a way that could mean that “cancer is no longer a death sentence”.
Cancer treatment today is no longer restricted to chemotherapy. Nowadays, targeted therapy is being preferred over the former to help minimize the damage due to strong drugs or radiation (in case of radiation therapy). In the opinion of doctors and researchers, this type of therapy can restrict the damage caused on the patient and even ease side effects like that of hair loss. Although procedures of this kind require equipment that is very complex, the biology behind its success is quite simple.
“No two cancers are alike, just like no two patients are alike” says Abilesh Gunasekar, founder of LabP53, an emerging cancer research laboratory. This statement is the fundamental principal to a large number of treatment related complications and even deaths. Cancer treatment, especially chemotherapy is a very invasive process, however it is also the only shot that some people have at survival. This is where Bioinformatics comes in. The human genome differs greatly from person to person and this is what makes every affected individual’s cancer different. Thus, by studying a person’s genome it is possible to understand what type of treatment will suit him. Bioinformatics tools can be used to generate ideal compound prototypes that can work against cancer and avoid those properties that harm the individual. This information can then be used to administer chemicals or combinations of chemicals that would befit the patient, in other words, it would be a personalized treatment, all that with just a few tissue samples.
This may not be the ultimate answer to curing cancer, however it is a major milestone in the fight against it. Not only does it rule out the need for trial and error based approaches, but also can prove to reduce costs of cancer treatment, thus help individuals and their families from ruling it out as losing battle.
The children of a certain Memphis based Hospital and Research institute are living testimony to the fact that personalized therapy is a less invasive and relatively more permanent cure for cancer. But what is personalized therapy and how has it been so successful? One way of explaining it, is that it is the kind of treatment that is tailor made, according to one’s needs or even genetic make-up. Its success lay mainly in its property of optimization (acting only as much as is necessary), which accounts also for its non-invasive character. The children at the above-mentioned hospital, suffered from a certain kind of leukemia. The standard procedure for the treatment of this disease was an invasive form of cranial radiation, however personalized therapy helped change that.
Although cranial radiation was the standard treatment for this type of cancer, it had some severe side effects. These side effects included second cancers, stunted growth, hormone imbalances and cognitive deficits. Taking these into consideration, doctors aimed at reducing the amount of radio therapy used to treat the patients, balancing it out by administering more suitable anticancer drugs (chemotherapy). Only patients with a high risk of relapse were given radiotherapy. Owing largely to the variety of new drugs being discovered nowadays, this proved to be quite successful in the treatment of the disease. With the progress of treatment, researchers have declared that it is now safe to eliminate radiation therapy entirely.
The uses and means of practicing personalized therapy are spread out over a broad spectrum. Imagine two patients undergoing treatment with drugs and medicines that they have never been administered before. In this scenario, it is always a risk to administer a drug, as we do not know how a patient will respond. A classic case of this lay in the metabolism of isoniazid; this drug gets modified into a different compound by chemical processes in the liver. There are two types of isoniazid metabolisms in patients, due to their genetic make-up; one type of patient metabolizes very slowly, the other very fast. Slow metabolism may cause peripheral neuritis whereas fast metabolism may cause liver toxicity. Thus how would a doctor know which patient type he is dealing with in order to regulate the dosage of the drug? This is where personalized therapy comes in. With the use of Pharmaco-genetic studies it is possible to compile a chart which summarizes all the patients genetic ally determined reactions to drugs.
The above are some of the examples of the many ongoing projects in the field of personalized therapy. This is not a wonder drug, neither is it a miracle machine, at best, it is merely a more intelligent way of using what we already have, to create the best possible cure. The role of genetics in personalized therapy is one that is emerging as a smarter and surer solution to cure and more importantly, prevent diseases and their side-effects. It strives to guarantee cent percent recovery without lasting scars. Doctors and researchers have taken a serious stand for this change and believe that this type of therapy is here to stay.
The moment you hear the word cancer, what is the first thought that comes into your mind?
For some it may be an unfortunate loss of a loved one, for a sufferer, it may be every word the doc has said while he/she is in treatment, however you would be surprised at the number of people that know more about the word in the context of ‘the zodiac’ than that of the disease. In any case, one wouldn’t be considered daft crazy if one knows nearly nothing about the disease, but then again, it is always better to be informed.
Many of us may not have realized how much Cancer has grown as a disease. With respect to records it started off as far back in time as 3000 B.C, as breast Cancer; when the great physicians of that era thought it to be a blockage in the milk ducts of the mammary glands. Now even the most common types of cancer alone, are more than the number of fingers on your hand.
Cancer today is found in most parts of the world. WHO has predicted its highest prevalence in the nations of Europe and the Americas. Numbers say that African and South East Asian countries have a rising rate of incidents and also a much smaller gap between the frequency of occurrence in men and women. According to WHO’s statistical analysis, on an average every one out of four individuals is likely to be affected by cancer. Although the statistics seem to say a lot per se, what still defines this disease to most is the social stigma attached to Cancer, its patients and its survivors. In today’s society while for some the word ‘Cancer’ seems to paint an image of a long, relentless struggle with a low chance of survival, others think of some forms of it as trivial. However, what really is cancer?
Cancer is an umbrella term covering a wide range of diseases that all have one thing in common: the uncontrolled growth and proliferation of cells. Normal body cells have a programmed death and a limited capacity of proliferation; however sometimes, a cell suffers from neoplasia, which means that it is no longer normal. In this case both, its growth as well as its division become aberrant. A mass of such cells is called neoplasm or tumour. In cancer neoplasm may also spread and invade nearby body tissues, damaging them in the process and rendering them malignant. The next question that comes to mind is: how do these cells become neoplastic and thus cancerous? This finds its answer in genetics.
A cell becomes cancerous due to certain basic genetic mutations, which involve the displacement of genetic elements (nitrogenous bases) from their correct places. This in turn leads to the formation of modified or abnormal cells. Generally two types of mutations may cause cancerous cells to develop:
On the whole, there are present certain genes that dictate cells to divide without regulation and this causes the formation of a tumour. Other genes are sometimes also modified such that they are unable to perform their normal functions and thus are unable to prevent cancer. Putting the two together Cancer is established. When one simplifies the matter as done above, it is plain to see that changes in the genetic level may be the key solution to our problems.
The treatment of cancer till now, concentrated majorly on symptomatic treatment using chemotherapy, radiotherapy and surgery. However none of the methods guaranteed a perfect recovery; chemotherapy being too invasive and radiotherapy, too dangerous. It wasn’t till recent times, that genetics came into the picture and the cause of cancer, although previously a foggy subject was now attributed to a mere change in one’s genes. With the advent of the age of the Human Genome Project and gene sequencing, scientists are uncovering newer more effective methods not only to modify genes but also detect and remedy slight changes in one’s genetic make-up. Today, there are hospitals which are coming up with methods as intensive as personalized therapy, where instead of the same cancer therapy on every patient, doctors collaborate with researchers to look into the genetic make-up of a person to better understand what therapy will fit the patient in particular. This has earned them nearly miraculous recoveries which all point to the fact that: turning our focus to the genetic aspect of cancer, may help us expedite our search for a cure, in the right direction.